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It is not yet clear whether these data driven methods for exploring beneficial and harmful drug effects are a genuine advance over traditional inferential approaches

Since tirzepatide is administered once weekly, some patients anecdotally report that morning administration (rather than evening) may help minimize any potential sleep interference, though this has not been formally studied

Because clinical trial outcomes included diet and exercise, Optum Rx has made the Weight Engage program available, equipping members with the behavioral support, monitoring and motivation they need to get the most out of their medications

Conflicts of Interest: From the study, several coauthors were Eli Lilly employees, and the sponsor designed and oversaw the trial, conducted site monitoring, data collation, and data analysis, with the last author also an employee of the sponsor